Each silver filling releases up to 17 mcg of mercury every day. This increases to 500 mcg with the smoking of cigarettes, drinking of hot liquids, gum chewing, acidic saliva or the grinding of teeth at night. Mercury accumulates in the brain, heart, kidneys and endocrine glands and can cause depression, auto-immune diseases, memory loss, tremors, anemia and heart attacks. An issue with mercury chelators (DMPS, DMSA and EDTA) is that they can release chelated mercury in exchange for other metals such as Cr2+ or Fe3+ for which they have a stronger affinity, leading to redeposition. While EDTA is the least problematic of the three, this is still a consideration . For this reason Medicardium also contains the trace mineral selenium which makes a non-reversible chemical bond to mercury rendering it permanently unavailable to the body and ready for detoxification.